This page contains selected publications which were done using CompuCell3D. While we try to keep this page updated some of the publications might be missing from it. If you want your CompuCell3D-based publication to be displayed here, please e-mail us ( mswat@indiana.edu )

Recent Publications

Somites Without a Clock - A.S.Dias, I.deAlmeida, J.M.Belmonte, J.A.Glazier, C.D.Stern. Science 343: 791-795 (Feb, 2014)

Dynamics of cell aggregates fusion: Experiments and simulations - Gilberto L. Thomas, Vladimir Mironov, Agnes Nagy-Mehez, José C.M. Mombach, Physica A 395: 247–254 (2014)

Hyaluronan: A critical regulator of endothelial-to-mesenchymal transition during cardiac valve formation - Anne Karine Lagendijk, András Szabo, Roeland M.H. Merks and Jeroen Bakkers, Trends in Cardiovascular Medicine (2013)

Vascular Networks Due to Dynamically Arrested Crystalline Ordering of Elongated Cells - Palm, Margriet M, and Roeland M H Merks, Phyiscal Review E 87: 012725 (2013)

Ph.D. Theses

Multi-Scale Cell-Based Computational Models of Vertabrate Segmentation and Somitogenesis Illuminate Coordination of Developmental Mechanisms Across Scales - Susan D. Hester. Ph.D. Indiana University, Department of Physics (April, 2012)

Vascular Patterning and Its Application in Cancer and Choroidal Neovascularization - A.Shirinifard. Ph.D. Indiana University, Department of Physics (March, 2012)

CompuCell3D - Based Simulations

Visualizing Cells and their Connectivity Graphs for CompuCell3D - R.Heiland, M.Swat, J.Sluka, B.Zaitlen, A.Shirinifard, G.Thomas, A.Lumsdaine, and J.Glazier. 2nd IEEE Symposium on Biological Data Visualization (October, 2012)

Adhesion Failures Determine the Pattern of Choroidal Neovascularization in the Eye: A Computer Simulation Study - A.Shirinifard, J.Glazier, M.Swat, J.S.Gens, F.Family, Y.Jiang and Hans E. Grossniklaus PLoS Comput Biol 7(10): e1002155. doi:10.1371/journal.pcbi.1002440 (May, 2012) ( IU press release, GSU press release )

Multi-Scale Modeling of Tissues Using CompuCell3D - M.Swat, G.Thomas, J.M.Belmonte, A.Shirinifard, D.Hmeljak and J.Glazier. Computational Methods in Cell Biology, Methods in Cell Biology 110: 325-366 (April, 2012)

Computer Simulations of Cell Sorting Due to Differential Adhesion - Ying Zhang, Gilberto L. Thomas, Maciej Swat, Abbas Shirinifard, James A. Glazier. PLoS One (2011)

A Multi-cell, Multi-scale Model of Vertebrate Segmentation and Somite Formation - Susan D. Hester, Julio M. Belmonte, J. Scott Gens, Sherry G. Clendenon, James A. Glazier. PLoS Comput Biol 7(10): e1002155 (2011) [The model and a movie are available]

Evolution and morphogenesis of differentiated multicellular organisms: autonomously generated diffusion gradients for positional information - Knabe, J.F., Nehaniv, C.L., Schilstra, M.J. Artificial Life XI: Proceedings of the Eleventh International Conference on the Simulation and Synthesis of Living Systems, pp. 321–328. MIT Press, Cambridge (2008)

Mathematical modeling of the capillary-like pattern generated by adrenomedullin-treated human vascular endothelial cells in vitro - Diego Guidolin, Giovanna Albertin, Elisa Sorato, Barbara Oselladore, Alessandra Mascarin, Domenico Ribatti

Simulation of Single-Species Bacterial-Biofilm Growth Using the Glazier-Graner-Hogeweg Model and the CompuCell3D Modeling Environment - Nikodem J. Poplawski, Abbas Shirinifard, Maciej Swat, and James A. Glazier, Mathematical biosciences and engineering 5, 355-388 (2008)

Discovering Novel Cancer Therapies: A Computational Modeling and Search Approach - Mahoney A. W., Smith B. G., Flann N. S., and Podgorski G. J., IEEE conference on Computational Intelligence in Bioinformatics and Bioengineering, (2008)

Adhesion Between Cells, Diffusion of Growth Factors, and Elasticity of the AER Produce the Paddle Shape of the Chick Limb - Nikodem J. Poplawski, Maciej Swat, J. Scott Gens and James A. Glazier. Physica A 373: 521-532 (2007)

Dynamical Mechanisms For Skeletal Pattern Formation in the Vertebrate Limb - H G E Hentschel, T Glimm, J A Glazier, S A Newman, Proc Biol Sci. 271, 1713–1722 (2004)

A Hybrid Discrete-Continuum Model for 3D Skeletogenesis of the Vertebrate Limb - R. Chaturvedi, C. Huang, J. A. Izaguirre, S. A. Newman, J. A. Glazier Lecture Notes in Computer Science 3305, 543-552 (2004)

CompuCell3D Framework

Computational Modeling of Angiogenesis: Towards a Multi-Scale Understanding of Cell–Cell and Cell–Matrix Interactions - Boas, Sonja E M, Margriet M Palm, Pieter Koolwijk, and Roeland M H Merks, Mechanical and Chemical Signaling in Angiogenesis (Springer, 2012), pp. 161–183

From Genes to Organisms Via the Cell: A Problem-Solving Environment for Multicellular Development - Trevor Cickovski, Kedar Aras, Maciej Swat, Roeland M. H. Merks, Tilmann Glimm, H. George E. Hentschel, Mark S. Alber, James A. Glazier, Stuart A. Newman, Jes A. Izaguirre, Computing in Science and Engineering, 9, 50-60 (2007)

A Framework For Three-Dimensional Simulation of Morphogenesis - Trevor M. Cickovski, Chengbang Huang, Rajiv Chaturvedi, Tilmann Glimm, H. George E. Hentschel, Mark S. Alber, James A. Glazier, Stuart A. Newman, Jesus A. Izaguirre, IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB), 2, 273-288 (2005)

On Multiscale Approaches to Three-Dimensional Modeling of Morphogenesis - R. Chaturvedi, C. Huang, B. Kazmierczak, T. Schneider, J. A. Izaguirre, T. Glimm, H. G. E. Hentschel, S. A. Newman, J. A. Glazier, M. Alber, Journal of The Royal Society Interface 2, 237-253 (2005)

A Cell-Centered Approach to Developmental Biology - Roeland M.H. Merks, and James A. Glazier, Physica A: Statistical Mechanics and its Applications 352, 113-130 (2005)

Empirical Evaluation of Design Patterns in Scientific Application - Kedar Aras, Master's Thesis, Dept. of Computer Science & Eng., Univ. of Notre Dame (2005)

CompuCell, a Multi-Model Framework For Simulation of Morphogenesis - J. A. Izaguirre, R. Chaturvedi, C. Huang, T. Cickovski, J. Coffland, G. Thomas, G. Forgacs, M. Alber, G. Hentschel, S. A. Newman, and J. A. Glazier, Bioinformatics 20, 1129-1137 (2004)

BIOLOGO: A Domain-Specific Language For Morphogenesis - Trevor M. Cickovski, Master's Thesis, Dept. of Computer Science & Eng., Univ. of Notre Dame (2004)

Vascular Patterning and Its Application in Cancer and Choroidal Neovascularization - A.Shirinifard. Ph.D. Indiana University, Department of Physics (March, 2012)