This page contains selected publications which were done using CompuCell3D. While we try to keep this page updated some of the publications might be missing from it. If you want your CompuCell3D-based publication to be displayed here, please e-mail us ( mthielme@indiana.edu )

For list of PhD and Master theses completed using CC3D please click here

How to cite CompuCell3D

• Multi-Scale Modeling of Tissues Using CompuCell3D – M. Swat, Gilberto L. Thomas, Julio M. Belmonte, A. Shirinifard, D.Hmeljak, J. A. Glazier, Computational Methods in Cell Biology, Methods in Cell Biology 110: 325-366 (2012)

Publications

2017

• Computational Model of Secondary Palate Fusion and Disruption - M. Shane Hutson, Maxwell C.K. Leung, Nancy Baker, Richard M. Spencer, and Thomas B. Knudsen, Chemical Research in Toxicology, DOI: 10.1021/acs.chemrestox.6b00350, (2017)

2016

• Virtual-Tissue Computer Simulations Define the Roles of Cell Adhesion and Proliferation in the Onset of Kidney Cystic Disease – Julio M. Belmonte, Sherry G. Clendenon, Guilherme M. Oliveira, Maciej H. Swat, Evan V. Greene, Srividhya Jeyaraman, James A. Glazier, and Robert L. Bacallao, Molecular Biology of the Cell 27: 3673-3685 (2016)

• Spheroid Formation of Hepatocarcinoma Cells in Microwells: Experiments and Monte Carlo Simulations – Yan Wang, Myung Hee Kim, Seyed R. Tabaei, Jae Hyeok Park, Kyuhwan Na, Seok Chung, Vladimir P. Zhdanov, Nam-Joon Cho, PLoS ONE 11(8): e0161915 (2016)

• A Computational Model of Peripheral Photocoagulation for the Prevention of Progressive Diabetic Capillary Occlusion – Thomas J. Gast, Xiao Fu, John Scott Gens, James A. Glazier, Journal of Diabetes Research vol. 2016, Article ID 2508381, 13 pages (2016) doi:10.1155/2016/2508381

• A Liver-Centric Multiscale Modeling Framework for Xenobiotics – James P. Sluka , Xiao Fu, Maciej Swat, Julio M. Belmonte, Alin Cosmanescu, Sherry G. Clendenon, John F. Wambaugh, James A. Glazier, PLoS ONE 11: e0162428 (2016)

• IL-2 sensitivity and exogenous IL-2 concentration gradient tune the productive contact duration of CD8+ T cell-APC: a multiscale modeling study – Xuefeng Gao, Christophe Arpin, Jacqueline Marvel, Sotiris A. Prokopiou, Olivier Gandrillon, Fabien Crauste, BMC Systems Biology 10:77 (2016)

• Filopodial-Tension Model of Convergent-Extension of Tissues – Julio M. Belmonte, Maciej H. Swat, James A. Glazier, PLoS Comput Biol 12: e1004952 (2016)

• Memory of cell shape biases stochastic fate decision-making despite mitotic rounding – Takashi Akanuma, Cong Chen, Tetsuo Sato, Roeland M. H. Merks, Thomas N. Sato, Nature Commun 7: 11963 (2016)

• Progression of Diabetic Capillary Occlusion: A Model – Xiao Fu, John Scott Gens, James A. Glazier, Stephen A. Burns, Thomas J. Gast, PLoS Comput Biol 12: e1004932 (2016)

• The Molecular Basis of Radial Intercalation during Tissue Spreading in Early Development – András Szabó, Isidoro Cobo, Sharif Omara, Sophie McLachlan, Ray Keller, Roberto Mayor, Developmental Cell 37: 213–225 (2016)

• Bystander effects and their implications for clinical radiation therapy: Insights from multiscale in silico experiments – Gibin George Powathil, Alastair J Munro, Mark Chaplain, Maciej H. Swat, Journal of Theoretical Biology 401: 1-14 (2016)

• Spatial Modeling of Drug Delivery Routes for Treatment of Disseminated Ovarian Cancer – Kimberly R. Kanigel Winner, Mara P. Steinkamp, Rebecca J. Lee, Maciej Swat, Carolyn Y. Muller, Melanie E. Moses, Yi Jiang, Bridget S. Wilson, Cancer Research 76(6): 1320–34 (2016)

• Proteolytic and non-proteolytic regulation of collective cell invasion: tuning by ECM density and organization – Sandeep Kumar, Aastha Kapoor, Sejal Desai, Mandar M. Inamdar, Shamik Sen, Scientific Reports 6: 19905 (2016)

2015

• Changing cell behaviours during beetle embryogenesis correlates with slowing of segmentation – A. Nakamoto, S. D. Hester, S. J. Constantinou, W. G. Blaine, A. B. Tewksbury, M. T. Matei, L. M. Nagy, T. A. Williams, Nat Commun 6: 6635 (2015)

• Fabrication of Biomimetic Bone Tissue Using Mesenchymal Stem Cell-Derived Three-Dimensional Constructs Incorporating Endothelial Cells – Jun-Ichi Sasaki, Masanori Hashimoto, Satoshi Yamaguchi, Yoshihiro Itoh, Itsumi Yoshimoto, Takuya Matsumoto, Satoshi Imazato, PLoS ONE 10(6): e0129266 (2015)

• Multi-scale modeling of cell survival and death mediated by p53 network: A Systems Pharmacology Framework – Yuan Wang, Zihu Guo, Xuetong Chen, Wenjuan Zhang, Aiping Lu, Yonghua Wang, Molecular BioSystems 11(6): 3011-3021 (2015)

• A Neutrophil Phenotype Model for Extracorporeal Treatment of Sepsis – Alexander D. Malkin, Robert P. Sheehan, Shibin Mathew, William J. Federspiel, Heinz Redl, Gilles Clermont, PLoS Comput Biol 11(10): e1004314 (2015)

• Development of cell differentiation in the transition to multicellularity: a dynamical modeling approach – Emilio Mora Van Cauwelaert, Juan A. Arias Del Angel, Mariana Benítez, Eugenio M. Azpeitia, Front Microbiol 6: 603 (2015)

• 3D Simulations of Wet Foam Coarsening Evidence a Self Similar Growth Regime – Gilberto L. Thomas, Julio M. Belmonte, Francois Graner, James A. Glazier, Rita M.C. de Almeida, Colloids and Surface A: Physicochemical and Engineering Aspects 473:109-114 (2015)

• Limited specificity of IRF3 and ISGF3 in the transcriptional innate-immune response to double-stranded RNA – Diana R. Ourthiague, Harry Birnbaum, Niklas Ortenlöf, Jesse D. Vargas, Roy Wollman, Alexander Hoffmann, Journal of Leukocyte Biology 98: 119-128 (2015)

• Emergent Stratification in Solid Tumors Selects for Reduced Cohesion of Tumor Cells: A Multi-Cell Model of Tumor Evolution Using CompuCell3D – Maciej Swat, Gilberto Thomas, Abbas Shirinifard, Sherry Clendenon, James Glazier, PLoS ONE 10(6): e0127972 (2015)

• Large-scale parameter studies of cell-based models of tissue morphogenesis using CompuCell3D or VirtualLeaf – Margriet Palm, Roeland Merks, In: Nelson, C.M. (ed.), Tissue Morphogenesis. Methods in Molecular Biology , Springer-Verlag Berlin Heidelberg, Methods Mol Biol 1189: 301-22 (2015)

• Modeling of the Urothelium with an Agent Based Approach – Angelo Torelli, Fabian Siegel, Philipp Erben, Markus Gumbel, Bioinformatics and Biomedical Engineering 9044: 375-385 (2015)

2014

• The Cell Behavior Ontology: Describing the intrinsic biological behaviors of real and model cells seen as active agents – James P. Sluka, Abbas Shirinifard, Maciej Swat, Alin Cosmanescu, Randy Heiland and James A. Glazier, Bioinformatics 30(16): 2367-74 (2014)

• Lattice-Based Model of Ductal Carcinoma In Situ Suggests Rules for Breast Cancer Progression to an Invasive State – Eline Boghaert, Derek C. Radisky, Celeste M. Nelson, PLoS Comput Biol 10(12): e1003997 (2014) DOI: 10.1371/journal.pcbi.1003997

• Using Mathematical Modelling as a Virtual Microscope to Support Biomedical Research – Chiara Giverso and Luigi Preziosi, Mathematical Models and Methods for Planet Earth Springer INdAM Series Volume 6, 2014, pp 59-71

• Integrating multi-scale knowledge on cardiac development into a computational model of ventricular trabeculation – Bouke A. de Boer, Jean-François Le Garrec,Vincent M. Christoffels, Sigolène M. Meilhac and Jan M. Ruijter, Wiley Interdisciplinary Reviews: Systems Biology and Medicine Volume 6, Issue 6, pages 389–397, November/December 2014

• Multiscale modeling of the early CD8 T cell immune response in lymph nodes: an integrative study – SA Prokopiou, L Barbarroux, S Bernard, JMafille, Y Leverrier, C Arpin, J Marvel, O Gandrillon, F Crauste, Computation 2(4): 159-181 (2014)

• Somites Without a Clock – Ana S. Dias, I. de Almeida, Julio M. Belmonte, J. A. Glazier, Claudio D. Stern, Science 343: 791-795 (2014)

• Dynamics of cell aggregates fusion: Experiments and simulations – Gilberto L. Thomas, Vladimir Mironov, Agnes Nagy-Mehez, José C. M. Mombach, Physica A 395: 247-254 (2014)

• Synergy of cell–cell repulsion and vacuolation in a computational model of lumen formation – Sonja E. M. Boas, Roeland M. H. Merks, J. R. Soc. Interface 11(92): 20131049 (2014)

• The effects of cell compressibility, motility and contact inhibition on the growth of tumor cell clusters using the Cellular Potts Model – Jonathan F. Li, John Lowengrub, Journal of Theoretical Biology 343: 79-91 (2014)

• Advances in Modelling of Epithelial to Mesenchymal Transition – R. Summers, T. Abdulla, J.-M. Schleich, XIII Mediterranean Conference on Medical and Biological Engineering and Computing 41: 1225-1228 (2014)

• A design principle underlying the paradoxical roles of E3 ubiquitin ligases – Daewon Lee, Minjin Kim & Kwang-Hyun Cho, Scientific Reports 4: 5573 (2014)

2013

• Agent-Based Virtual Tissue Simulations – Maciej Swat, James A. Glazier, Biomedical Computation Review, Fall 2013 p.28-29

• A Cellular Potts Models Simulating Cell Migration on and in Matrix Environments – Marco Scianna, Luigi Preziosi, Katarina Wolf, Mathematical Biosciences and Engineering 10(1), (2013)

• Individual Cell-Based Model for In-Vitro Mesothelial Invasion of Ovarian Cancer – C. Giverso, M. Scianna, L. Preziosi, N. Lo Buono, A. Funaro, Mathematical Modelling of Natural Phenomena, DOI:http://dx.doi.org/10.1051/mmnp/20105109

• Cell-Based Multi-Parametric Model of Cleft Progression during Submandibular Salivary Gland Branching Morphogenesis – Shayoni Ray, Daniel Yuan, Nimit Dhulekar, Basak Oztan, Bülent Yener, Melinda Larse, PLoS Comput Biol 9(11):e1003319 (2013)

• Hyaluronan: A critical regulator of endothelial-to-mesenchymal transition during cardiac valve formation – Anne Karine Lagendijk, András Szabo, Roeland M.H. Merks and Jeroen Bakkers, Trends in Cardiovascular Medicine 23(5): 135-142 (2013)

• Ovarian Tumor Attachment, Invasion, and Vascularization Reflect Unique Microenvironments in the Peritoneum: Insights from Xenograft and Mathematical Models – Mara P. Steinkamp, Kimberly Kanigel Winner, Bridget S. Wilson, Frontiers in Oncology 3:97 (2013)

• A Computational Model Predicting Disruption of Blood Vessel Development – Nicole Kleinstreuer, David Dix, Michael Rountree, Nancy Baker, Nisha Sipes, David Reif, Richard Spencer, Thomas Knudsen, PLoS Comput Biol 9(4): e1002996 (2013)

• Vascular Networks Due to Dynamically Arrested Crystalline Ordering of Elongated Cells – Margriet M. Palm, Roeland M. H. Merks,. Phyiscal Review E 87: 012725 (2013)

• Acute and Fractionated Irradiation Differentially Modulate Glioma Stem Cell Division Kinetics – Xuefeng Gao, J. Tyson McDonald, Lynn Hlatky, Heiko Enderling, Cancer Res March 1, 73; 1481 (2013)

2012

• Multiscale Developments of the Cellular Potts Model – Marco Scianna, Luigi Preziosi, Multiscale Model. Simul. 10(2):342–382. (2012)

• Adhesion Failures Determine the Pattern of Choroidal Neovascularization in the Eye: A Computer Simulation Study – A. Shirinifard, J. A. Glazier, M. Swat, J. S. Gens, F. Family, Y. Jiang, Hans E. Grossniklaus, PLoS Comput Biol 7(10): e1002155 (2012) [ IU press release, GSU press release ]

• Hybrid cellular Potts model for solid tumor growth – M. Scianna, L. Preziosi, in M. Chaplain, J. Batzel, M. Bachar, Eds., New Challenges for Cancer Systems Biomedicine, p.205-224, Springer, (2012)

• Searching a multicellular model to tame tumor-induced angiogenesis – Podgorski, G.J., Flann, N.S. Computational Intelligence in Bioinformatics and Computational Biology (CIBCB), 2012 IEEE Symposium on DOI: 10.1109/CIBCB.2012.6217251 , pp. 349-354 (2012)

• Epithelial to mesenchymal transition: The roles of cell morphology, labile adhesion and junctional coupling – Tariq Abdulla, Luis Luna-Zurita, José Luis De La Pompa, Jean-Marc Schleich, Ron Summers, Computer Methods And Programs In Biomedicine 111:435-446 (2012)

• Modelling: Computing Cancer – N. Savage, Nature 491:S62–S63 (2012)

• Multiscale modelling of Notch-mediated lateral induction – Abdulla T., Schleich, J., Summers, R., Biomedical and Health Informatics (BHI), IEEE-EMBS International Conference, p. 257 – 260 (2012)

• Multi-Scale Modeling of Tissues Using CompuCell3D – M. Swat, Gilberto L. Thomas, Julio M. Belmonte, A. Shirinifard, D.Hmeljak, J. A. Glazier, Computational Methods in Cell Biology, Methods in Cell Biology 110: 325-366 (2012)

• Integrating Intracellular Dynamics Using CompuCell3D and Bionetsolver: Applications to Multiscale Modelling of Cancer Cell Growth and Invasion – Vivi Andasari, Ryan T. Roper, Maciej H. Swat, Mark A. J. Chaplain, PLoS ONE 7(3): e33726 (2012)

• Workflows for parameter studies of multi-cell modeling – Randy Heiland, Maciek Swat, Benjamin Zaitlen, James A. Glazier, Andrew Lumsdaine, Proceedings of the 2010 Spring Simulation Multiconference p. 94 (2012)

• Visualizing Cells and their Connectivity Graphs for CompuCell3D – R. Heiland, M. Swat, J. Sluka, B. Zaitlen, A. Shirinifard, G. Thomas, A. Lumsdaine, J. Glazier, 2nd IEEE Symposium on Biological Data Visualization (2012)

2011

• A Multi-cell, Multi-scale Model of Vertebrate Segmentation and Somite Formation – Susan D. Hester, Julio M. Belmonte, J. Scott Gens, Sherry G. Clendenon, James A. Glazier, PLoS Comput Biol 7(10): e1002155 (2011) [ model and a movie are available ]

• MDCK Cystogenesis Driven by Cell Stabilization within Computational Analogues – Jesse A. Engelberg, Anirban Datta, Keith E. Mostov, C. Anthony Hunt, PLoS Comput Biol 7(4): e1002030 (2011)

• A Multiscale Model for Hypoxia-induced Avascular Tumor Growth – Xuefeng Gao, Mark Tangney, Sabin Tabirca, Proceedings of 2011 International Conference on Bioscience, Biochemistry and Bioinformatics IPCBEE vol.5 (2011)

• Computational modelling of epithelial to mesenchymal transition – T. Abdulla, R. Imms, J.-L. Dillenseger, J.-M. Schleich, R. Summers, IRBM, 32(5):306–310 (2011)

• Computer Simulations of Cell Sorting Due to Differential Adhesion – Ying Zhang, Gilberto L. Thomas, Maciej Swat, Abbas Shirinifard, James A. Glazier, PLoS ONE 6(10):e24999 (2011)

• Towards multiscale systems modeling of endocardial to mesenchymal transition – Abdulla T, Imms, R., Schleich, J., Summers R., Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE, p. 449 – 452 (2011)

• Coordination of Cell Differentiation and Migration in Mathematical Models of Caudal Embryonic Axis Extension – Nigel C. Harrison, Ruth Diez del Corral, Bakhtier Vasiev, PLoS ONE 6(7):e22700 (2011)

2010

• Modeling Gastrulation in the Chick Embryo: Formation of the Primitive Streak – Bakhtier Vasiev, Ariel Balter, Mark Chaplain, James A. Glazier, Cornelis J. Weijer, PLoS ONE 5(5):e10571 (2010)

• Front Instabilities and Invasiveness of Simulated 3D Avascular Tumors – Nikodem J. Popławski, Abbas Shirinifard, Ubirajara Agero, J. Scott Gens, Maciej Swat, James A. Glazier, PLoS ONE 5(5): e10641 (2010)

• A Computer Simulation of Long-Range Patterning in the Drosophila Pupal Eye – David Larson , Ruth Johnson, Maciej H. Swat, J. Cordero, James A. Glazier, Ross Cagan, PLoS Comput Bio 6: e1000841 (2010) doi:10.1371/journal.pcbi.1000841

2009

• 3D Multi-Cell Simulation of Tumor Growth and Angiogenesis – Abbas Shirinifard, J. Scott Gens, Benjamin L. Zaitlen, Nikodem J. Popławski, Maciej Swat, James A. Glazier, PLoS ONE 4(10):e7190 (2009)

• Mathematical modeling of the capillary-like pattern generated by adrenomedullin-treated human vascular endothelial cells in vitro – Diego Guidolin, Giovanna Albertin, Elisa Sorato, Barbara Oselladore, Alessandra Mascarin, Domenico Ribatti, Dev Dyn 238(8):1951-63 (2009)

2008

• Evolution and morphogenesis of differentiated multicellular organisms: autonomously generated diffusion gradients for positional information – J. F. Knabe, C. L. Nehaniv, M. J. Schilstra, Artificial Life XI: Proceedings of the Eleventh International Conference on the Simulation and Synthesis of Living Systems, pp. 321–328. MIT Press, Cambridge (2008)

• Simulation of Single-Species Bacterial-Biofilm Growth Using the Glazier-Graner-Hogeweg Model and the CompuCell3D Modeling Environment – Nikodem J. Popławski, Abbas Shirinifard, Maciej Swat, James A. Glazier, Mathematical biosciences and engineering 5: 355-388 (2008)

• Discovering Novel Cancer Therapies: A Computational Modeling and Search Approach – A. W. Mahoney, B. G. Smith, N. S. Flann, G. J. Podgorski, IEEE conference on Computational Intelligence in Bioinformatics and Bioengineering, pp. 233-240 (2008)

• Coordinated Action of N-CAM, N-cadherin, EphA4, and ephrinB2 Translates Genetic Prepatterns into Structure during Somitogenesis in Chick – James A. Glazier, Ying Zhang, Maciej Swat, Benjamin Zaitlen, Santiago Schnell, Current Topics in Developmental Biology 81:205-247 (2008)

2007

• From Genes to Organisms Via the Cell: A Problem-Solving Environment for Multicellular Development – Trevor Cickovski, Kedar Aras, Maciej Swat, Roeland M. H. Merks, Tilmann Glimm, H. George E. Hentschel, Mark S. Alber, James A. Glazier, Stuart A. Newman, J. A. Izaguirre, Computing in Science and Engineering 9: 50-60 (2007)

• Adhesion Between Cells, Diffusion of Growth Factors, and Elasticity of the AER Produce the Paddle Shape of the Chick Limb – Nikodem J. Popławski, Maciej Swat, J. Scott Gens, James A. Glazier, Physica A 373: 521-532 (2007)

2005

• A Framework For Three-Dimensional Simulation of Morphogenesis – Trevor M. Cickovski, Chengbang Huang, Rajiv Chaturvedi, Tilmann Glimm, H. George E. Hentschel, Mark S. Alber, James A. Glazier, Stuart A. Newman, Jesus A. Izaguirre, IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB) 2: 273-288 (2005)

• On Multiscale Approaches to Three-Dimensional Modeling of Morphogenesis – R. Chaturvedi, C. Huang, B. Kazmierczak, T. Schneider, J. A. Izaguirre, T. Glimm, H. G. E. Hentschel, S. A. Newman, J. A. Glazier, M. Alber, J. R. Soc. Interface 2: 237-253 (2005)

• A Cell-Centered Approach to Developmental Biology – Roeland M.H. Merks, James A. Glazier, Physica A 352: 113-130 (2005)

2004

• Dynamical Mechanisms For Skeletal Pattern Formation in the Vertebrate Limb – H. G. E. Hentschel, T. Glimm, J. A. Glazier, Stuart A. Newman, Proc Biol Sci 271(1549): 1713-1722 (2004)

• A Hybrid Discrete-Continuum Model for 3D Skeletogenesis of the Vertebrate Limb – R. Chaturvedi, C. Huang, J. A. Izaguirre, Stuart A. Newman, J. A. Glazier, Lecture Notes in Computer Science 3305: 543-552 (2004)

• CompuCell, a Multi-Model Framework For Simulation of Morphogenesis – J. A. Izaguirre, R. Chaturvedi, C. Huang, T. Cickovski, J. Coffland, G. Thomas, G. Forgacs, M. Alber, G. Hentschel, S. A. Newman, and J. A. Glazier, Bioinformatics 20: 1129-1137 (2004)