$\frac{\mathrm{QGut}\mathrm{CArt}}{\mathrm{VArt}}$ $\mathrm{kGutabs}\mathrm{AGutlumen}$ $\frac{\mathrm{QCardiac}\mathrm{CLung}}{\mathrm{VLung}}$ $\frac{\mathrm{QCardiac}\mathrm{CVen}}{\mathrm{VVen}}$ $\frac{\mathrm{QRest}\mathrm{CArt}}{\mathrm{VArt}}$ $\frac{\frac{\frac{\mathrm{QRest}\mathrm{CRest}\mathrm{Ratioblood2plasma}}{\mathrm{KRest2plasma}}}{\mathrm{Fraction\_unbound\_plasma}}}{\mathrm{VRest}}$ $\frac{\mathrm{QLiver}\mathrm{CArt}}{\mathrm{VArt}}$ $\frac{\frac{\frac{\mathrm{CLmetabolism}\mathrm{CLiver}}{\mathrm{Kliver2plasma}}}{\mathrm{Fraction\_unbound\_plasma}}}{\mathrm{VLiver}}$ $\frac{\mathrm{QGut}\mathrm{CGut}}{\mathrm{VGut}}$ $\frac{\frac{\frac{(\mathrm{QLiver}+\mathrm{QGut})\mathrm{CLiver}\mathrm{Ratioblood2plasma}}{\mathrm{Kliver2plasma}}}{\mathrm{Fraction\_unbound\_plasma}}}{\mathrm{VLiver}}$ $\frac{\mathrm{QKidney}\mathrm{CArt}}{\mathrm{VArt}}$ $\frac{\frac{\mathrm{Qgfr}\mathrm{CKidney}}{\mathrm{Kkidney2plasma}}}{\mathrm{VKidney}}$ $\frac{\frac{\frac{\mathrm{QKidney}\mathrm{CKidney}\mathrm{Ratioblood2plasma}}{\mathrm{Kkidney2plasma}}}{\mathrm{Fraction\_unbound\_plasma}}}{\mathrm{VKidney}}$